Season and sear. Preheat the oven to 300°F (150°C). Combine the brown sugar, smoked paprika, garlic powder, onion powder, oregano, salt, and pepper. Coat the beef with olive oil and the seasoning mixture. Sear in batches for 2–3 minutes per side until browned.
Braise. Sauté the onion and garlic in the same pot. Add the beef broth, apple cider vinegar, and Worcestershire sauce. Return the beef to the pot, cover tightly, and braise at 300°F (150°C) for 3–3½ hours, until fork-tender. Alternatively, cook in a slow cooker on LOW for 7–8 hours.
Shred. Transfer the tender beef to an oven-safe baking dish. Shred with two forks, retaining some larger chunks. Reserve approximately ½ cup of braising liquid.
Coat with glaze. Combine the barbecue sauce, honey, and reserved braising liquid. Add enough glaze to coat the shredded beef evenly without leaving it swimming in liquid.
Caramelize. Spread the beef in a shallow layer. Bake uncovered at 400°F (200°C) for 15–20 minutes, checking regularly, until the glaze is thick, sticky, and caramelized around the edges.